| 2021-07-13 19:00:00July 13, 2021 | Copetown FC vs Waterdown Bulldogs | 2 - 6 | |
| 2021-07-13 21:00:00July 13, 2021 | BCFC vs Wentworth FC | 1 - 2 | |
| 2021-07-14 21:00:00July 14, 2021 | Dundas Assault vs Ancaster FC | 4 - 3 | |
| 2021-07-15 21:00:00July 15, 2021 | Hamilton Thunder vs York | 1 - 1 | |
| 2021-07-20 19:00:00July 20, 2021 | Ancaster FC vs Waterdown Bulldogs | 4 - 0 | |
| 2021-07-20 21:00:00July 20, 2021 | Wentworth FC vs Copetown FC | 5 - 0 | |
| 2021-07-21 21:00:00July 21, 2021 | York vs BCFC | 1 - 1 | |
| 2021-07-22 21:00:00July 22, 2021 | Dundas Assault vs Hamilton Thunder | 0 - 2 | |
| 2021-07-27 19:00:00July 27, 2021 | Copetown FC vs Ancaster FC | 0 - 2 | |
| 2021-07-27 21:00:00July 27, 2021 | Hamilton Thunder vs Waterdown Bulldogs | 2 - 2 | |
| 2021-07-28 21:00:00July 28, 2021 | Wentworth FC vs York | 5 - 0 | |
| 2021-07-29 21:00:00July 29, 2021 | BCFC vs Dundas Assault | 1 - 4 | |
| 2021-08-03 19:00:00August 3, 2021 | York vs Copetown FC | 0 - 3 | |
| 2021-08-03 21:00:00August 3, 2021 | Waterdown Bulldogs vs BCFC | 1 - 2 | |
| 2021-08-04 21:00:00August 4, 2021 | Dundas Assault vs Wentworth FC | 2 - 4 | |
| 2021-08-05 21:00:00August 5, 2021 | Ancaster FC vs Hamilton Thunder | 2 - 2 | |
| 2021-08-10 19:00:00August 10, 2021 | Hamilton Thunder vs Copetown FC | 3 - 0 | |
| 2021-08-10 21:00:00August 10, 2021 | York vs Dundas Assault | 0 - 3 | |
| 2021-08-11 21:00:00August 11, 2021 | Wentworth FC vs Waterdown Bulldogs | 2 - 0 | |
| 2021-08-12 21:00:00August 12, 2021 | BCFC vs Ancaster FC | 3 - 5 | |
| 2021-08-17 19:00:00August 17, 2021 | Waterdown Bulldogs vs York | 5 - 0 | |
| 2021-08-17 21:00:00August 17, 2021 | Copetown FC vs Dundas Assault | 1 - 3 | |
| 2021-08-18 21:00:00August 18, 2021 | Hamilton Thunder vs BCFC | 1 - 1 | |
| 2021-08-19 21:00:00August 19, 2021 | Ancaster FC vs Wentworth FC | 3 - 2 | |
| 2021-08-24 19:00:00August 24, 2021 | BCFC vs Copetown FC | 4 - 2 | |
| 2021-08-24 21:00:00August 24, 2021 | Wentworth FC vs Hamilton Thunder | 1 - 1 | |
| 2021-08-25 21:00:00August 25, 2021 | Dundas Assault vs Waterdown Bulldogs | 4 - 1 | |
| 2021-08-26 21:00:00August 26, 2021 | York vs Ancaster FC | 0 - 6 | |
| 2021-08-31 19:00:00August 31, 2021 | York vs Hamilton Thunder | 1 - 1 | |
| 2021-08-31 21:00:00August 31, 2021 | Ancaster FC vs Dundas Assault | 0 - 2 | |
| 2021-09-01 21:00:00September 1, 2021 | Waterdown Bulldogs vs Copetown FC | 5 - 2 | |
| 2021-09-02 21:00:00September 2, 2021 | Wentworth FC vs BCFC | 1 - 0 | |
| 2021-09-07 19:00:00September 7, 2021 | Hamilton Thunder vs Dundas Assault | 2 - 3 | |
| 2021-09-07 21:00:00September 7, 2021 | Waterdown Bulldogs vs Ancaster FC | 1 - 4 | |
| 2021-09-08 21:00:00September 8, 2021 | Copetown FC vs Wentworth FC | 0 - 4 | |
| 2021-09-09 21:00:00September 9, 2021 | BCFC vs York | 4 - 1 | |
| 2021-09-14 19:00:00September 14, 2021 | Waterdown Bulldogs vs Hamilton Thunder | 1 - 3 | |
| 2021-09-14 21:00:00September 14, 2021 | York vs Wentworth FC | 1 - 5 | |
| 2021-09-15 21:00:00September 15, 2021 | Dundas Assault vs BCFC | 4 - 0 | |
| 2021-09-16 21:00:00September 16, 2021 | Ancaster FC vs Copetown FC | 5 - 1 | |
| 2021-09-21 19:00:00September 21, 2021 | Copetown FC vs York | 4 - 0 | |
| 2021-09-21 21:00:00September 21, 2021 | BCFC vs Waterdown Bulldogs | 3 - 1 | |
| 2021-09-22 21:00:00September 22, 2021 | Wentworth FC vs Dundas Assault | 1 - 2 | |
| 2021-09-23 21:00:00September 23, 2021 | Hamilton Thunder vs Ancaster FC | 4 - 0 | |
| 2021-09-28 19:00:00September 28, 2021 | Copetown FC vs Hamilton Thunder | 1 - 1 | |
| 2021-09-28 21:00:00September 28, 2021 | Waterdown Bulldogs vs Wentworth FC | 1 - 4 | |
| 2021-09-29 21:00:00September 29, 2021 | Ancaster FC vs BCFC | 0 - 3 | |
| 2021-09-30 21:00:00September 30, 2021 | Dundas Assault vs York | 6 - 1 | |
| 2021-10-05 19:00:00October 5, 2021 | Dundas Assault vs Copetown FC | 5 - 2 | |
| 2021-10-05 21:00:35October 5, 2021 | BCFC vs Hamilton Thunder | 2 - 1 | |
| 2021-10-06 21:00:34October 6, 2021 | York vs Waterdown Bulldogs | 2 - 1 | |
| 2021-10-07 21:00:00October 7, 2021 | Wentworth FC vs Ancaster FC | 5 - 1 | |
| 2021-10-12 19:00:00October 12, 2021 | Hamilton Thunder vs Wentworth FC | 0 - 3 | |
| 2021-10-12 21:00:00October 12, 2021 | Ancaster FC vs York | 7 - 2 | |
| 2021-10-13 21:00:00October 13, 2021 | Waterdown Bulldogs vs Dundas Assault | 1 - 6 | |
| 2021-10-14 21:00:00October 14, 2021 | Copetown FC vs BCFC | 0 - 3 | |
